Neurocode Labs, Inc. is dedicated to offering sequencing to help determine the influence of genetics on neurological disease, and furthering the understanding of genetics in the practice of both pediatric and adult neurology. We also offer clients the opportunity to further the understanding of various neurological disorders by requesting they allow us to contribute data to ongoing research efforts in areas such as seizure disorders, dementia, and parkinsonism.
Whole Exome Sequencing
We target the coding sequence of the human genome, and then focus on a set of genes either known or suspected to be associated with various neurological conditions.
We maintain, mine and ethically share genetic knowledge for maximum benefit. Exome sequencing may yield a lifetime of insight, to individuals and society. Research is performed with the University of British Columbia and the global community of professionals, patients and public who care.
“In genetic medicine, our goals are to promote rapid innovation and provide accurate, clinically meaningful results." - Matthew Farrer
Neurocode Labs, Inc. offers testing centred around the practice of neurology. Physicians can request sample kits and order testing for their patients. Our testing is done by whole exome sequencing, which is then focused on a set of genes either known or suspected to be associated with various neurological conditions. Up to three likely causative or pathogenic mutations associated with the phenotype will be validated by Sanger sequencing, and a report will be returned to the referring physician. Turn-around time for all testing is eight weeks. No STAT test ordering is currently available. To request information or advice regarding the testing we offer, or the proper testing to order, please contact us. The full results of exome sequencing can be made available to the physician for more comprenensive genetic counselling or investigation, as well as any research collaborations to which the patient has consented.
For physician-ordered whole exome sequencing for seizure disorders from approved clinicians at BC Children's Hospital:
For physician-ordered whole exome sequencing for other diagnostic use that will be paid privately:
Instructions for filling out the test requisition are available here (requires PDF reading software).
A set of 1,214 genes is interrogated for both known and potentially novel causative mutations. Please see the list of covered genes here.
This test also includes bioinformatics analysis, periodic re-reporting, and one Sanger validation of a potentially causative mutation.
Cost: $3000 CAD
With DAP accreditation, Neurocode Labs, Inc. can also offer clinical confirmation of mutations discovered in other facilities. Results will be returned to the requesting facility.
Cost: $250 CAD
Neurocode Labs, Inc. is dedicated to ensuring all questions regarding the results of the sequencing we perform are answered. Medical, scientific, technical and informatics experts are all available to answer any questions our clients may have about any of our processes; the applicability and reliability of results; and the processes involved behind the data we generate. If you have questions, please do not hesitate to contact us.
Accuracy and reliability of sequencing results are the most important part of Neurocode's laboratory operations. At certain times, Neurocode Labs may need to send a sample submitted to us to a referral laboratory for sequencing at no additional cost to the user. If this happens, users or laboratory services will be notified before the sample is sent, and the results of that testing will be included in the report Neurocode Labs sends back.
At present, Neurocode Labs does not send any samples to referral labs for sequencing. Please contact us if you have questions about the referral lab process.
We accept packages on regular work days, Monday through Friday. Please do not request Saturday delivery. For international shipping, a commercial (ProForma) invoice is required on the outside package along with the waybill. A sample invoice for DNA is available. Please be sure to also include a customs declaration form.
Blood, DNA and saliva samples can be shipped at room temperature. For blood and DNA samples, express delivery is recommended. Blood samples collected on a Friday or over the weekend should be kept at 4°C and shipped on the next business day with overnight delivery. Keeping the specimen refrigerated over the weekend will not compromise sample quality.
Package the specimen(s) according to approved transportation policies. Include the completed test requisition form in the shipping container. Ensure name and identifying number on the specimen match those on the test requisition form and clearly indicate the test being ordered. Incomplete forms will result in either delay of testing, or sample rejection. Incorrectly stored or transported samples will result in sample rejection.
Fresh peripheral whole blood is our preferred specimen type. We also accept saliva as well as DNA. We offer kits for either blood or saliva specimen collection; please contact us at firstname.lastname@example.org to request a kit.
Blood should be collected in an EDTA (lavender top) vacutainer tube and spun lightly to avoid partial clotting.
Saliva samples should be collected using an Oragene kit, or a Neurocode Rinse kit. Collect the sample into the tube provided according to the instructions included with the kit. Please contact us at email@example.com for a saliva collection kit for patients that cannot provide a blood sample.
Isolated genomic DNA samples can be sent in any sterile plastic tube. Information regarding:
must be included with the sample.
Neurocode Labs, Inc. is incorporated under the laws of British Columbia, Canada. Our provincial business number is BC1042695.
Neurocode Labs, Inc. is accredited as a Molecular Diagnostic Laboratory under British Columbia's Diagnostic Accreditation Program. Our certificate number is 061301, expiry 2019-03-14.
Dr. Frykman is licensed to practice medicine in British Columbia. College of Physicians and Surgeons of BC ID: 29971, registration number: 50041.
Neurocode labs, Inc. Incorporation
Let's get in touch. Send us a message:
For general inquiries, comments, questions, or concerns.
Monday - Friday 9:00 to 17:00 (Closed all statutory holidays)The lab is not open to the public; we have no facilities to perform sample draws from patients. Please see our Tests and Sending Samples pages for details on how to submit samples for sequencing.