Overview
This test is for the detection of AQP4 antibodies to establish a neuromyelitis optica (NMO) diagnosis and distinguish NMOSD from multiple sclerosis.
Test code: | AQP4 CBA |
Abbreviations, alternate names: | AQP4 Ab, NMOSD CBA, NMO CBA |
Methodology: | In-house live cell-based assay (CBA) |
Validation: | Laboratory developed test (LDT) |
Requirements
Specimen type: | Serum |
Minimum volume: | 0.5 mL |
Preferred volume: | 3 mL |
Rejection criteria: | Grossly hemolytic, lipemic, or icteric. If the sample arrives at room temperature. |
Our offices are only able to receive samples Mon-Fri, so samples must be shipped Mon-Thur. Samples arriving over the weekend may need to be re-drawn.
Specimen
Specimen collection: | No patient preparation is required for sample collection. |
Specimen handling: | Centrifuge SST tubes at 1800 - 2200 x g for 10-15 minutes |
Specimen stability: | Serum may be stored: |
Performance
Testing frequency: | On demand |
Turnaround time: | 1 week |
Reference range: | N/A |
Additional Information
- This test was developed and its performance characteristics determined by BCNI. The test was performed in a DAP, CAP and CLIA certified laboratory and is intended for clinical purposes
- Please indicate if patients are on immunomodulating treatments as these may interfere with testing.
- Aquaporin-4 antibodies are found in 75% of neuromyelitis optica (NMO). Diagnosis of NMO requires extensive acute myelitis and optic neuritis. While a positive result for AQP4 Ab is diagnostic, a negative result does not rule out an NMO diagnosis.
Order Aquaporin-4 Antibodies by Live Cell-Based Assay (AQP4 CBA) Test
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