Overview
| Test code: | GFAP |
| Abbreviations, alternative names: | Plasma GFAP |
| Methodology: | Chemiluminescence assay (CLEIA) |
| Validation: | Laboratory Developed Test (LDT) |
Requirements
| Specimen type: | EDTA plasma |
| Minimum volume: | 0.5 mL |
| Preferred volume: | 5 mL |
| Rejection criteria: | Grossly hemolytic, lipemic, or icteric. If the sample arrives at room temperature |
Our offices are only able to receive samples Mon-Sat, so samples must be shipped Mon-Fri. Samples arriving Sunday may need to be re-drawn.
Specimen
GFAP is extremely sensitive to temperature and free/thaw cycles. It is critical that time at room temperature be minimized. Refrigerate when not handling, and immediately after sample has been centrifuged and aliquoted.
| Specimen collection: | Overnight fasting is recommended |
| Specimen handling: | Centrifuge EDTA tubes at 3,000 - 3,500 rpm for 10-15 minutes (use refrigerated centrifuge, if available) |
| Specimen storage: | Plasma samples must either be refrigerated and shipped chilled within 24 hours of collection, or frozen and shipped on dry ice |
| Specimen stability: | Serum samples may be stored: |
Performance
| Testing frequency: | Once per week |
| Turnaround time: | 1 week |
| Reference range: | < 78.2 ng/L (age 45-65) |
| Clinical performance: | A-beta PET-Positive vs HC: AUC of 0.96 at Youden index of 93.25 ng/L |
| Validation: | Laboratory Developed Test (LDT) |
Additional Information
Order Plasma Glial Fibrillary Acidic Protein (GFAP) Test
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Ordering Process