Overview
This test assists in the diagnosis of autoimmune myasthenia gravis (MG) with acetylcholine receptor (AChR) antibodies.
It provides a more sensitive test for AChR antibodies that may be present in double-seronegative samples, but undetectable by standard detection methods such as radioimmunoprecipitation assay (RIPA) or enzyme-linked immunosorbent assay (ELISA).
Test code: | AChR CBA |
Abbreviations, alternate names:: | Clustered AchR Ab, AchR Ab |
Methodology: | In-house live cell-based assay (CBA) |
Requirements
Specimen type: | Serum |
Minimum volume: | 0.5 mL |
Preferred volume: | 3 mL |
Rejection criteria | Grossly hemolytic, lipemic, or icteric. If the sample arrives at room temperature. |
Our offices are only able to receive samples Mon-Fri, so samples must be shipped Mon-Thur. Samples arriving over the weekend may need to be re-drawn.
Specimen
Specimen collection: | No patient preparation is required for sample collection. |
Specimen handling: | Centrifuge SST tubes at 1800 - 2200 x g for 10-15 minutes |
Specimen stability: | Serum samples may be stored: |
Performance
Testing frequency: | Once a week |
Turnaround time: | 2-7 days |
Reference Range: | N/A |
Additional Information
- This test was developed and its performance determined by Neurocode USA Inc. It has not been cleared or approved by the Food and Drug Administration.
- Please indicate if patients are on immunomodulating treatments as these may interfere with testing.
- Causal antibodies cannot be identified in about 10% of MG cases. Therefore, a positive result is specific for the diagnosis of AChR ab myasthenia gravis (MG), but a negative result does not rule out an MG diagnosis.
Order Acetylcholine Receptor Antibodies by Live Cell-Based Assay (AChR CBA) Test
Reach out to our specialists today to start the ordering process.
Order Test