Overview
This test assists in the diagnosis of autoimmune myasthenia gravis (MG) with acetylcholine receptor (AChR) antibodies.
It provides a more sensitive test for AChR antibodies that may be present in double-seronegative samples, but undetectable by standard detection methods such as radioimmunoprecipitation assay (RIPA) or enzyme-linked immunosorbent assay (ELISA).
| Test code: | AChR CBA |
| Abbreviations, alternate names:: | Clustered AchR Ab, AchR Ab |
| Methodology: | In-house live cell-based assay (CBA) |
Requirements
| Specimen type: | Serum |
| Minimum volume: | 0.5 mL |
| Preferred volume: | 3 mL |
| Rejection criteria | Grossly hemolytic, lipemic, or icteric. If the sample arrives at room temperature. |
Our offices are only able to receive samples Mon-Fri, so samples must be shipped Mon-Thur. Samples arriving over the weekend may need to be re-drawn.
Specimen
| Specimen collection: | No patient preparation is required for sample collection. |
| Specimen handling: | Centrifuge SST tubes at 1800 - 2200 x g for 10-15 minutes |
| Specimen stability: | Serum samples may be stored: |
Performance
| Testing frequency: | Once a week |
| Turnaround time: | 2-7 days |
| Reference Range: | N/A |
Additional Information
- This test was developed and its performance determined by Neurocode USA Inc. It has not been cleared or approved by the Food and Drug Administration.
- Please indicate if patients are on immunomodulating treatments as these may interfere with testing.
- Causal antibodies cannot be identified in about 10% of MG cases. Therefore, a positive result is specific for the diagnosis of AChR ab myasthenia gravis (MG), but a negative result does not rule out an MG diagnosis.
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