Overview


This test is for the detection of VGCC antibodies to aid in the diagnosis of Lambert-Eaton myasthenic syndrome (LEMS)

Test code:

VGCC RIPA
Abbreviations, alternate names:

VGCC Ab, VGCC RIPA
Methodology:

In-house radioimmunoprecipitation assay (RIPA)
Validation:

In vitro diagnostics (IVD)

Requirements


Specimen type:

Serum
Minimum volume:

0.5 mL
Preferred volume:

3 mL
Rejection criteria:

Grossly hemolytic, lipemic, or icteric. If the sample arrives at room temperature.

Our offices are only able to receive samples Mon-Fri, so samples must be shipped Mon-Thur. Samples arriving over the weekend may need to be re-drawn.

Specimen


Specimen collection:

No patient preparation is required for sample collection.
Draw blood in tube(s) with SST activator (5mL gold top or 8.5mL tiger top).
Invert tubes 8 times to ensure complete mixing.
Specimen handling:

Centrifuge SST tubes at 1800 - 2200 x g for 10-15 minutes
Draw off serum (top layer) into Aliquot tubes with pipette, ensuring not to take gel or RBC (middle/bottom layers)
Store Aliquot tubes in refrigerator (2°C - 8°C) until shipping.
Specimen stability:

Serum samples may be stored:
Up to 7 days refrigerated (2 – 8⁰C)
-20⁰C for longer term storage – avoid subsequent freeze thaws

Performance


Testing frequency:

TBD
Turnaround time:

TBD
Reference range:

Negative: ≤ 30
Positive: > 30

Additional Information


Please indicate if patients are on immunomodulating treatments as these may interfere with testing.

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